Tisha San Miguel Selected Research

Neoplasms (Cancer)

1/2020	Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
11/2019	The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
10/2016	Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.
7/2011	Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives.
3/2011	Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors.

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Tisha San Miguel Research Topics

Disease

5	Neoplasms (Cancer) 01/2020 - 03/2011
1	Sickle Cell Anemia (Hemoglobin S Disease) 10/2016
1	Arthritis (Polyarthritis) 10/2016
1	Inflammation (Inflammations) 01/2015
1	Autoimmune Diseases (Autoimmune Disease) 01/2015
1	Rodent Diseases 01/2015

Drug/Important Bio-Agent (IBA)

1	sotorasibIBA 01/2020
1	Proteins (Proteins, Gene)FDA Link 11/2019
1	Cysteine (L-Cysteine)FDA Link 11/2019
1	N- (1- (7- fluoro- 2- (pyridin- 2- yl)quinolin- 3- yl)ethyl)- 9H- purin- 6- amineIBA 01/2015
1	Protein Kinases (Protein Kinase)IBA 01/2015
1	Phosphotransferases (Kinase)IBA 03/2011

Therapy/Procedure

2	Therapeutics 10/2016 - 07/2011